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affinity maturation

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00:55 Oct 28, 2020
English to Czech translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: affinity maturation
Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):
  • Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
  • An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
  • We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS
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GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
5afinitní maturace
Martin Janda


  

Translations offered


7 hrs   confidence: Answerer confidence 5/5
afinitní maturace


Definition from wikipedia.org:
Afinitní maturace je imunologický proces, který umožňuje B-lymfocytům vyvinout protilátky s lepší afinitou k antigenu. Když se imunitní systém setká s tímto antigenem (například nějakým mikroorganismem) opakovaně, je schopen vytvořit protilátky, které se na něj lépe („silněji“) vážou. Tzv. sekundární odpověď zahrnuje protilátky s afinitou vyšší až o několik řádů.[1]

Example sentence(s):
  • Ostatní mutantní B-lymfocyty, které jej vážou slabě nebo vůbec ne, během tohoto procesu, zvaného afinitní maturace, hynou. Výsledkem afinitní maturace je vznik optimalizované varianty původní buňky, schopné produkovat velmi kvalitní vysokoafinní protilátky. - vesmir.cz  
  • Po rozeznání antigenu na FDC v primárních lymfoidních folikulech a po obdržení pomocných signálů od specifických pomocných lymfocytů Th začne nové kolo dělení a diferenciace B lymfocytů v procesu zvaném afinitní maturace. - remedia.cz  
Martin Janda
Czech Republic
Local time: 03:59
Native speaker of: Native in CzechCzech
PRO pts in category: 61
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