affinity maturation

Hungarian translation: affinitásérés

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00:55 Oct 28, 2020

English to Hungarian translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals

English term or phrase: affinity maturation

Definition from Johns Hopkins Medicine:
the process through which B cells mature and produce antibodies that have a greater affinity for their antigenic target. This process is more prominent when the immune response is well under way.

Example sentence(s):

Collectively, structural studies of affinity maturation have shown that increased antibody affinity can arise from any one or any combination of multiple diverse mechanisms, including improved shape complementarity at the interface with antigen, increased buried surface area upon complex formation, additional interfacial polar or hydrophobic interactions, and preorganization or rigidification of the antigen-binding site. Frontier in Immunology
An understanding of how affinity maturation occurs at multiple stages of the antigen-driven B-cell immune response provides insights into the overall design of B-cell immune responses. ScienceDirect
We show how affinity maturation in this lineage has maintained adaptability (“breadth” of neutralizing activity) by generating a branched and, hence, diversifying phylogeny PNAS

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Hungarian translation:affinitásérés

Definition:
A B-sejtek érésének folyamata, amelynek során a termelődő antitesteknek a korábbiaknál magasabb affinitása lesz az antigéncélpontjaikkal szemben.

Selected response from:

András Illyés

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affinitásérés

András Illyés

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peer agreement (net): +2

affinitásérés

Definition from own experience or research:
A B-sejtek érésének folyamata, amelynek során a termelődő antitesteknek a korábbiaknál magasabb affinitása lesz az antigéncélpontjaikkal szemben.

Example sentence(s):

Affinitásérés: egyre hatékonyabb antitestek keletkeznek, ezáltal az immunválasz gyorsabb és effektívebb lesz. - Immunológiai alapfogalmak
A specifikus ellenanyagok affinitásának az immunválasz előrehaladtával, illetve többszöri antigéninger hatására bekövetkező növekedése. - Magyar Tudomány
A helper T-sejtek stimulálják a B-sejtek klonális osztódását, az izotípusváltást, az affinitásérést és a memóriasejtekké való differenciálódást. - Immunológia

András Illyés
Local time: 10:42
Native speaker of:

Hungarian
PRO pts in category: 76

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affinity maturation

Hungarian translation: affinitásérés

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