Glossary entry (derived from question below)
English term or phrase:
drug-drug interaction studies
German translation:
Studien zu Arzneimittel-Wechselwirkungen
English term
Italy
drug-drug interaction studies with
Clinical Pharmacology Summary
Drug interaction studies with laropiprant
- No clinically meaningful effect on warfarin and digoxin
- No effect on rosiglitazone (CYP2C8 substrate)
- No significant alteration of plasma levels from oral contraceptives containing ethinyl estradiol
- No effect on midazolam PK (CYP3A4 substrate)
- Laropiprant is an inhibitor of UGT2B4 and UGT2B7
- Clarithromycin (strong CYP3A4 inhibitor) does not alter laropiprant PK to a clinically meaningful degree
***Drug-drug interaction studies with*** ER niacin/laropiprant
- Modest increase in simvastatin acid (AUC 60%, Cmax 40%) attributed to ER niacin
Special populations
- Renal insufficiency (severe CrCl < 30 mL/min/1.73 m2)
-- Modest (not clinically significant) effect on laropiprant AUC
- Moderate hepatic insufficiency
-- Has a significant impact on laropiprant pharmacokinetics, 3-fold increase in laropiprant AUC
-- As with other niacin products, ER niacin/laropiprant is contraindicated in patients with significant hepatic dysfunction
Ich steh hier grad vollkommen auf dem Schlauch und komm nicht mehr weiter. Wie heissen diese "drug-drug interaction studies" auf Deutsch, bzw. wie muss ich diesen Satz formulieren.
Ich bin dankbar um jeden neuen Ansatz, der mir dabei helfen kann, meinen Knoten zu lösen.
MTIA
| 3 +11 | Studien zu Arzneimittel-Wechselwirkungen |
Johanna Timm, PhD
|
| 5 +1 | Studien zu Arzneimittelwechselwirkungen mit |
Blaess
|
| 3 | Pharmazeutika-Interaktionssudie |
Rolf Keiser
|
Aug 17, 2009 17:47: Klaus Urban changed "Term asked" from "Drug-drug interaction studies with" to "drug-drug interaction studies with"
Non-PRO (2): robin25, Harald Moelzer (medical-translator)
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Proposed translations
Canada
Friendly, fast & certified!
Native in: German (Variants: Swiss, Platt / Nieder (Low German), Austrian, Germany) 
Works in: English to German, German to English, German
Studien zu Arzneimittel-Wechselwirkungen
oder: zu Arzneimittelinteraktionen
cf.: "Arzneimittelinteraktionen
synonym: IA, Arzneimittel-Wechselwirkungen, Drug-Drug-Interactions, DDI"
Switzerland
Translate complexity through simplicity
Native in: English (Variants: US, British) 
, German (Variants: Germany, Swiss)
Works in: German to English, English to German, English, and 1 more.
Pharmazeutika-Interaktionssudie
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