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原書のテキスト - ドイツ語 Allgemeine Datenschutzerklärung
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翻訳 - イタリア語 Informativa generale sulla privacy
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英語 から イタリア語: Clinical study outcomes General field: 医療 Detailed field: 医療: 製薬
原書のテキスト - 英語 Glick I.D. et al (2008)2 examined aripiprazole treatment of patients with comorbid schizophrenia and obsessive-compulsive symptoms (OCS) that did not meet full criteria for obsessive-compulsive disorder (OCD). Physically healthy adults aged 18 to 65 years with DSM-IV schizophrenia and a minimum score of 16 on the Yale-Brown Obsessive Compulsive Scale (YBOCS) were eligible to participate in this 6-week, open-label, flexible-dose trial of aripiprazole monotherapy. Patients currently taking another antipsychotic medication were concurrently down-titrated from their current antipsychotic and up-titrated with aripiprazole, starting with 15 mg/day. Coadministration of the 2 medications lasted from 7 to 14 days, until a stable therapeutic dose of 10 to 30 mg/day was reached. Subjects were recruited into the study, which was conducted at the Schizophrenia Clinic of Stanford University School of Medicine, between January 2005 and December 2006. Of 15 eligible patients, 7 completed the trial. All 7 had at least minimal improvement on the YBOCS, the Clinical Global Impressions (CGI) scale, and the Positive and Negative Syndrome Scale (PANSS). At week 6, the mean CGI-Improvement scale score was 2.3 (much improved). Mean PANSS scores decreased from 75 to 56, a mean decrease of 21%, (p < .05). On the YBOCS, 6 of 7 completers showed a change of greater than 35% from baseline to week 6. Authors concluded that aripiprazole monotherapy can modestly improve the outcome for some schizophrenia patients with obsessive-compulsive symptoms and further studies with aripiprazole under controlled conditions are indicated for this population of patients. Authors added that, overall, even modest improvement in global functioning due to an improvement in an OCS component may be clinically meaningful for this difficult-to-treat subset of schizophrenia patients.
翻訳 - イタリア語 Glick I.D. et al (2008)2 hanno esaminato il trattamento con aripiprazolo in pazienti con schizofrenia concomitante e sintomi ossessivo-compulsivi (SOC) che non soddisfacevano in pieno i criteri del disturbo ossessivo-compulsivo (DOC). I soggetti adulti, fisicamente sani, di età compresa tra 18 e 65 anni con schizofrenia DSM-IV e un punteggio minimo di 16 alla scala YBOCS (Yale-Brown Obsessive Compulsive Scale) erano idonei alla partecipazione in questo studio clinico della durata di 6 settimane, in aperto, a dose flessibile, sulla monoterapia a base di aripiprazolo. I pazienti che attualmente stavano assumendo un altro farmaco antipsicotico ne hanno ridotto la dose e hanno aumentato quella di aripiprazolo, a partire da 15 mg/die. La somministrazione contemporanea dei 2 farmaci è durata dai 7 ai 14 giorni, fino al raggiungimento di una dose terapeutica stabile di 10 - 30 mg/die. I soggetti sono stati arruolati nello studio, che è stato condotto presso la Schizophrenia Clinic della Stanford University School of Medicine, tra gennaio 2005 e dicembre 2006. Su 15 pazienti idonei, 7 hanno completato lo studio. Tutti e 7 avevano presentato almeno un minimo miglioramento alle scale YBOCS, CGI (Clinical Global Impressions) e PANSS (Positive and Negative Syndrome Scale). Alla settimana 6, il punteggio medio secondo la scala CGI-Improvement era 2,3 (molto migliorato). I punteggi medi alla scala PANSS erano diminuiti da 75 a 56, una riduzione media del 21%, (p< 0,05). Nei punteggi YBOCS, 6 dei 7 pazienti che hanno completato lo studio hanno mostrato una variazione maggiore del 35% dal basale alla settimana 6. Gli autori hanno concluso che la monoterapia a base di aripiprazolo è in grado di migliorare in maniera modesta gli esiti di alcuni pazienti con schizofrenia e sintomi ossessivo-compulsivi e che per questa popolazione di pazienti sono indicati altri studi con aripiprazolo in condizioni controllate. Gli autori hanno aggiunto che, complessivamente, anche un miglioramento modesto della funzionalità globale dovuto al miglioramento di un componente SOC può essere clinicamente significativo in questo sottogruppo di pazienti schizofrenici di difficile trattamento.
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翻訳教育
Bachelor's degree - Università degli Studi di Milano
体験
翻訳体験年数： 6. ProZ.comに登録済み: Oct 2017. 入会日： Oct 2017.
資格
英語 から イタリア語 (Università degli Studi di Milano, verified) 日本語 から イタリア語 (Università degli Studi di Milano, verified)
メンバーシップ
N/A
ソフトウェア
Crowdin, Microsoft Excel, Microsoft Word, SmartCAT, Passolo, Powerpoint, Trados Studio, Wordfast
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入会時期 Oct '17
