Tomasso Sep 13, 2021:

DLT ??? Я цілком припускаю, але це схоже за змістом та термінами The same difficulty arises with rapid accrual. Suppose that the DLT of a new agent can be assessed in the first 28-day cycle; if the accrual rate is 8 patients/28 days, then on average, five new patients will accrue while waiting to evaluate the previous three patients’ outcomes, and we must determine how to provide them with timely treatment. To quantify the severity of such logistic difficulty, Jin et al (4) defined the logistic difficulty index (LDI) = accrual rate × length of the DLT assessment window, where LDI ≤ 1 respresents no or minimal logistic difficulty as by the time a new patient is accrued, patients accrued previously are expected to complete their DLT assessment; and a larger value of LDI > 1 means increasingly severe logistic difficulty to determine a dose for new patients as more patients are expected to have their DLT data pending. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191365/