This site uses cookies. Some of these cookies are essential to the operation of the site, while others help to improve your experience by providing insights into how the site is being used. For more information, please see the ProZ.com privacy policy.
Cookie settings
  1. KudoZ™ Top
  2. English to Serbian
  3. Medical: Pharmaceuticals

amenable mutations

Serbian translation: mutacije koje (dobro) reaguju (na tretman / lek)

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:amenable mutations
Serbian translation:mutacije koje (dobro) reaguju (na tretman / lek)
Entered by: Svetomir Mijovic

12:57 Nov 20, 2022
English to Serbian translations [PRO]
Medical - Medical: Pharmaceuticals / pharmacological tests
English term or phrase: amenable mutations
In one or more embodiments, mutant forms of α-Gal A are considered to be amenable to migalastat are defined as showing a relative increase (+10 µM migalastat) of >1.20-fold and an absolute increase (+ 10 µM migalastat) of ≥ 3.0% wild-type (WT) when the mutant form of α-Gal A is expressed in HEK-293 cells (referred to as the "HEK assay") according to Good Laboratory Practice (GLP)-validated in vitro assay (GLP HEK or Migalastat Amenability Assay). Such mutations are also referred to herein as "HEK assay amenable" mutations....
HEK assay amenable mutations include at least those mutations listed in a pharmacological reference table (e.g., the ones recited in the U.S. or International Product labels for a migalastat product such as GALAFOLD®). As used herein, "pharmacological reference table" refers to any publicly accessible written or electronic record, included in either the product label within the packaging of a migalastat product (e.g., GALAFOLD®) or in a website accessible by health care providers, that conveys whether a particular mutation or variant is responsive to migalastat (e.g., GALAFOLD®) PC therapy, and is not necessarily limited to written records presented in tabular form.
Svetomir Mijovic
Serbia
Local time: 22:01
mutacije koje (dobro) reaguju (na tretman / lek)
Explanation:
"An amenable mutation is a genetic change or variant that a person may have that is responsive - amenable - to treatment."

--------------------------------------------------
Note added at 13 hrs (2022-11-21 01:57:27 GMT)
--------------------------------------------------

Još bolji prevod za "amenable" bi bio "responzivne".

--------------------------------------------------
Note added at 13 hrs (2022-11-21 01:59:04 GMT)
--------------------------------------------------

"responzivne mutacije"
Selected response from:

Milan Nesic
Grading comment
Hvala!
4 KudoZ points were awarded for this answer



Summary of answers provided
5mutacije koje (dobro) reaguju (na tretman / lek)
Milan Nesic


  

Answers


8 mins   confidence: Answerer confidence 5/5
mutacije koje (dobro) reaguju (na tretman / lek)


Explanation:
"An amenable mutation is a genetic change or variant that a person may have that is responsive - amenable - to treatment."

--------------------------------------------------
Note added at 13 hrs (2022-11-21 01:57:27 GMT)
--------------------------------------------------

Još bolji prevod za "amenable" bi bio "responzivne".

--------------------------------------------------
Note added at 13 hrs (2022-11-21 01:59:04 GMT)
--------------------------------------------------

"responzivne mutacije"


    https://www.drugs.com/medical-answers/amenable-mutation-3560832/
Milan Nesic
Native speaker of: Native in SerbianSerbian
PRO pts in category: 120
Grading comment
Hvala!
Login to enter a peer comment (or grade)



Login or register (free and only takes a few minutes) to participate in this question.

You will also have access to many other tools and opportunities designed for those who have language-related jobs (or are passionate about them). Participation is free and the site has a strict confidentiality policy.

Return to KudoZ list

KudoZ™ translation help

The KudoZ network provides a framework for translators and others to assist each other with translations or explanations of terms and short phrases.

See also:
ProZ.com term search
Search millions of term translations
Close search
Term search
  • All of ProZ.com
  • Term search
  • Jobs
  • Forums
  • Multiple search