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allemand vers anglais: Head and Neck Squamous Cell Carcinoma DE - ENG General field: Médecine
Texte source - allemand Plattenepithelkarzinome der Kopf-Hals-Region (HNSCC) zählen seit Jahren zu den weltweit häufigsten Krebsarten. Trotz vieler Bemühungen hat sich das 5-Jahres-Überleben bei Patienten mit HNSCC kaum verbessert. Um einen Fortschritt zu erzielen, ist es notwendig, die der Erkrankung zugrunde liegenden biologischen Prozesse besser zu verstehen. Neben den bekannten genetischen Veränderungen haben molekular-zytogenetische Untersuchungen bei HNSCC gezeigt, dass es weitere Veränderungen gibt, die mit Vermehrung und Verlust chromosomaler Bereiche einhergehen, für die jedoch die krankheitsverursachenden Gene bisher nicht identifiziert wurden. Darüberhinaus haben jüngste Forschungsergebnisse verdeutlicht, dass epigenetische Modifikationen wie die DNA Methylierung eine wichtige Rolle spielen. So konnte gezeigt werden, dass bei HNSCC eine Reihe von Genen (z.B. das Tumorsuppressorgen CDKN2A sowie DAPK1, MGMT, TIMP3, TCF21, und C/EBPα) hypermethylierte Bereiche in regulatorischen DNA Sequenzen aufweisen, wodurch ihre Expression verringert oder unterbunden wird. Die Hypermethylierung solcher Gene könnte als Biomarker zur Früherkennung von HNSCC genutzt werden und nicht zuletzt dadurch zur Verbesserung von Prävention und Therapieerfolg beitragen.
Traduction - anglais World-wide, squamous cell carcinomas of the head and neck (HNSCC) have been among the most common cancers for years. Despite significant efforts, the 5-year survival rate in HNSCC patients has improved very little. In order to achieve progress, it is necessary to gain a better understanding of the biological processes that underlie this disease. In addition to the well-known genetic changes, molecular cytogenetic analysis of HNSCC has identified additional changes associated with duplications or deletions of chromosomal domains, but for which disease-causing genes have not been identified. Furthermore, recent research has demonstrated that epigenetic modifications, such as DNA methylation play an important role. It was shown that a series of genes (e.g. the tumor suppressor gene CDKN2A, as well as DAPK1, MGMT, TIMP3, TCF21, and C/EBPα) show hypermethylation domains in their regulatory DNA sequences, resulting in their reduced or suppressed expression. Hypermethylation of these genes might serve as biomarkers for early diagnosis of HNSCC, and might contribute to improved prevention and therapeutic success.
français vers anglais: HIV in developing countries FRA - ENG General field: Médecine
Texte source - français Des estimations récentes de l’Organisation Mondiale de la Santé (OMS) pointent les progrès réalisés dans la lutte contre la pandémie du virus HIV. Cependant, 33,3 millions de personnes sont porteuses d’une infection HIV avec 2,9 millions de nouveaux cas par an. Deux tiers de ces personnes vivent dans des pays en voie de développement (PVD) à ressources limitées, en particulier pour l’accès aux soins. Par ailleurs, le taux d’infection HIV est en augmentation dans plusieurs pays d’Europe de l’est ou d’Asie centrale. Globalement, la moitié des personnes infectées par le virus HIV sont des femmes et l’OMS estime que 1800 bébés naissent quotidiennement porteurs du virus HIV, car leurs mères n’ont pas accès aux soins ou aux médicaments pour cette infection.
Traduction - anglais Recent estimates by the World Health Organization (WHO) show progress in the fight against the HIV pandemic. Nevertheless, there are 33.3 million people living with an HIV infection, with 2.9 million new cases per year. Two thirds of infected persons live in developing countries with limited resources, and limited access to health care in particular. Furthermore, the rate of HIV infection is increasing in several Eastern European and Central Asian countries. Globally, half of all HIV-infected persons are women, and the WHO estimates that each year, 1800 babies are born infected with HIV because their mothers lack access to care or to medication to control the infection.
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Années d'expérience en traduction : 12. Inscrit à ProZ.com : Mar 2013.
I hold a Ph.D. degree in Pathology from the University of Rochester School of Medicine and Dentistry in Rochester, New York, USA. I have worked in the health sciences, pharmaceutical, and biotechnology sectors in the United States for over two decades, and have a deep understanding of biomedical science as well as the quality, legal, and regulatory requirements of the pharmaceutical, diagnostics, and medical device industries. This unique background allows me to provide translation services that are scientifically accurate and comply with the highest industry standards.
Having been born and raised in Germany, I am a native speaker of German. I have also studied French and English in Germany. I performed my first translations of scientific manuscripts in graduate school, and have had the opportunity to continue translating manuscripts, procedures, and protocols as part of my work in international pharmaceutical and diagnostics companies. I have also completed a four-year professional assignment in France, deepening my knowledge of the French language.
The field of biomedical translation is specialized. It takes a translator with expertise who not only knows the languages but one who can make sense out of complex scientific documents. One who has the knowledge, education and work experience. I offer the highest degree of accuracy and understanding of biomedical science-related documents in the field.
Translation expertise in scientific manuscripts, protocols, medical reports, quality documents, instructions for use, as well as general correspondence and legal documents, including patents and contracts.
Detail-oriented, Technologically knowledgeable, Continuous learning and improvement, Good communication skills, Quality work, Reliable, Motivated.
Cet utilisateur a gagné des points KudoZ en aidant d'autres traducteurs sur des termes de niveau PRO. Cliquez sur le total des points pour afficher les traductions proposées.
Total des points gagnés: 107 Points de niveau PRO: 99
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