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Sample translations submitted: 1
English to Indonesian: Instruction for Use PocketChem General field: Tech/Engineering Detailed field: Chemistry; Chem Sci/Eng
Source text - English TEST CARTRIDGE PREPARATION AND
INTEGRITY CHECK
Allow at least 50 minutes for unopened cartridges to
equilibrate to the analyzer’s environmental
temperature before use, even if previously stored at
room temperature. Do not use heaters to warm the
cartridges.
Check that the foil seal covering the top of the
cartridge is not damaged. If the foil seal is damaged
then the cartridge must not be used.
If problems are experienced, contact your local
distributor or contact customer support on 022
32043204 or [email protected]
INTENDED USE
The PocketChemTM A1c Test is intended for the in
vitro quantitative determination of glycated
hemoglobin (HbA1c) in whole blood obtained from
finger prick or from venous blood samples collected
into EDTA tubes.
The PocketChemTM A1c Test is indicated in the
management and treatment of diabetes mellitus and
for monitoring long term glycemic control in patients
diagnosed with diabetes.
The PocketChemTM A1c Test is designed for
professional use only.
SUMMARY AND EXPLANATION OF THE
PocketChemTM A1c TEST
Human red blood cells (erythrocytes) are freely
permeable to glucose present in the surrounding
liquid (plasma) of the blood.
During the lifetime of the erythrocytes (normally up to
120 days) exposure to blood glucose results in
binding of glucose to the hemoglobin A molecule
present in erythrocytes. This is referred to as glycated
hemoglobin(1).
Chronic elevated blood glucose will result in tissue
and organ damage(2).
Good control of blood glucose, evident as lower
HbA1c values, has been proven to result in delayed
onset and slower progression of these
complications(2,3).
PRINCIPLE OF THE TEST
The PocketChemTM A1c Test Cartridge contains all of
the reagents required for the determination of
glycated hemoglobin in whole blood.
The PocketChemTM A1c Test combines the chemical
binding of boronate to glycated hemoglobin with the
fluorescent quenching effect that this binding exerts
on a fluorescent marker bound to the boronate
molecule.
After removing the foil seal, the cartridge is placed in
the PocketChemTM A1c Analyzer.
When instructed, the user pushes a mixing bead
containing the fluorescent boronate conjugate into
the buffer contained within the cartridge, using the
blunt end of the Sample Stick, and the analyzer
automatically rehydrates it.
The user then places the blood sample, contained on
the Sample Stick, gently into the top of the cartridge,
breaks off and removes the handle and closes the
door of the analyzer to introduce the blood sample it
into the buffer.
The analyzer automatically mixes the blood sample to
release the hemoglobin from the erythrocytes.
The total hemoglobin concentration is determined
from the initial decrease in the fluorescent signal.
The fluorescent boronate conjugate binds to the
glycated hemoglobin, which is measured by
monitoring a decrease in the fluorescence of the
active ingredient.
Translation - Indonesian PEMERIKSAAN INTEGRITAS DAN PERSIAPAN CARTRIDGE TES
Biarkan cartridge tidak terbuka selama sekurang-kurangnya 50 menit agar dapat seimbang dengan suhu lingkungan penganalisa sebelum digunakan, bahkan jika sebelumnya telah disimpan pada suhu ruangan.
Pastikan kertas segel yang menutupi bagian atas cartridge tidak rusak. Jika kertas segel rusak maka cartridge tidak boleh digunakan.
Jika ada masalah, hubungi distributor lokal anda atau hubungi layanan konsumen di 022 32043204 atau [email protected]
TUJUAN PENGGUNAAN
Tes PocketChem™ A1c dimaksudkan untuk penetapan kuantitatif In Vitro atau hemoglobin terglikasi (HbA1c di seluruh darah yang diperoleh dari tusukan di jari atau dari sampel pembuluh darah yang dikumpulkan kedalam tabung EDTA.
Tes PocketChem™ A1c terlihat pada manajemen dan pengobatan diabetes melitus dan untuk memonitor kontrol glikemik jangka panjang pada pasien yang didiagnosa diabetes.
Tes PocketChem™ A1c hanya dirancang untuk penggunaan profesional.
RANGKUMAN DAN PENJELASAN TES PocketChem™ A1c
Sel darah merah manusia (eritrosit) bebas ditembus oleh glukosa yang berada di sekitar cairan (plasma) darah.
Selama masa hidup eritrosit (biasanya mencapai 120 hari) paparan hasil glukosa darah dalam mengikat glukosa dengan hemoglobin, terdapat sebuah molekul dalam eritrosit. Hal ini disebut segabai Hemoglobin Terglikasi (1).
Glukosa darah kronis akan menyebabkan kerusakan jaringan dan organ (2).
Kontrol yang bagus terhadap glukosa darah, terbukti sebagai nilai HbA1c yang lebih rendah, telah terbukti menyebabkan penundaan onset dan perkembangan yang lebih lembat dari komplikasi ini (2,3).
PRINSIP TES
Cartridge Tes PocketChem™ A1c berisi semua reagen yang dibutuhkan untuk penetapan homoglobin terglikasi di dalam darah.
Tes PocketChem™ A1c menggabungkan ikatan boronate pada hemoglobin terglikasi dengan efek pendinginan fluoresensi yang digunakan ikatan ini pada penanda ikatan fluoresensi pada molekul boronate.
Setelah membuka kertas segel, cartridge diletakkan di penganalisa PocketChem™ A1c.
Ketika diinstruksikan, pengguna mendorong campuran tetesan yang berisi fluoresensi boronate dan mengkonjugasikan kedalam penyangga yang terdapat didalam cartridge, menggunakan ujung tumpul dari tongkat sampel, dan penganalisa secara otomatis meremajakannya.
Pengguna kemudian menempatkan sampel darah, yang terdapat dalam tongkat sampel, dengan perlahan ke bagian atas cartridge, berhenti sejenak dan lepaskan pegangan dan tutup pintu penganalisa untuk mengenalkan sampel darah pada penyangga.
Penganalisa secara otomatis mencampur sampel darah untuk melepaskan hemoglobin dari eritrosit.
Total konsentrasi hemoglobin ditentukan dari penurunan awal di sinyal fluoresensi.
Fluoresensi boronate mengkonjugasikan ikatan pada hemoglobin terglikasi, yang diukur dengan memonitor penurunan di fluoresensi bahan aktif.
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Translation education
Bachelor's degree - Universitas Negeri Padang (State University of Padang, Indonesia)
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Years of experience: 11. Registered at ProZ.com: Nov 2014.
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